Protein domains in Prosite database.
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| AP endonucleases family 2 signature 2 | [GSARY]-[LIVMF]-[CT]-[LIVMFY]-D-T-C-H. |
| AP endonucleases family 2 signature 3 | [LIVMFW]-H-x-N-[DEG]-[SA]-x(4)-[GNAQ]-x(3)-D-x-H. |
| Apoptosis regulator, Bcl-2 family BH1 motif signature | [LVMENQ]-[FTLS]-x-[GSDECQ]-[GLPCKH]-x(1,2)-[NST]-[YW]-G-[RK]-[LIV]-[LIVC]-[GAT]-[LIVMF](2)-x-F-[GSAEC]-[GSARY]. |
| Apoptosis regulator, Bcl-2 family BH2 motif signature | W-[LIM]-x(3)-[GR]-G-[WQ]-[DENSAV]-x-[FLGA]-[LIVFTC]. |
| Apoptosis regulator, Bcl-2 family BH3 motif signature | [LIVAT]-x(3)-L-[KARQ]-x-[IVAL]-G-D-[DESG]-[LIMFV]-[DENSHQ]-[LVSHRQ]-[NSR]. |
| Apoptosis regulator, Bcl-2 family BH4 motif signature | [DS]-[NT]-R-[AE]-[LI]-V-x-[KD]-[FY]-[LIV]-[GHS]-Y-K-L-[SR]-Q-[RK]-G-[HY]-x-[CW]. |
| Apple domain | C-x(3)-[LIVMFY]-x(5)-[LIVMFY]-x(3)-[DENQ]-[LIVMFY]-x(10)-C-x(3)-C-T-x(4)-C-x-[LIVMFY]-F-x-[FY]-x(13,14)-C-x-[LIVMFY]-[RK]-x-[ST]-x(14,15)-S-G-x-[ST]-[LIVMFY]-x(2)-C. |
| ArgE / dapE / ACY1 / CPG2 / yscS family signature 1 | [LIV]-[GALMY]-[LIVMF]-{Q}-[GSA]-H-x-D-[TV]-[STAV]. |
| ArgE / dapE / ACY1 / CPG2 / yscS family signature 2 | [GSTAI]-[SANQCVIT]-D-x-K-[GSACN]-x(1,2)-[LIVMA]-x(2)-[LIVMFY]-x(12,17)-[LIVM]-x-[LIVMF]-[LIVMSTAGC]-[LIVMFA]-x(2)-[DNGM]-E-E-x(0,1)-[GSTNE]. |
| Arginase family signature 1 | [LIVMF]-G-G-x-H-x-[LIVMT]-[STAV]-x-[PAG]-x-{A}-x-[GSTA]. |
| Arginase family signature 2 | [LIVM](2)-{A}-[LIVMFY]-D-[AS]-H-x-D. |
| Arginase family signature 3 | [ST]-[LIVMFY]-D-[LIVM]-D-x(3)-[PAQ]-x(3)-P-[GSA]-x(7)-G. |
| Argininosuccinate synthase signature 1 | [ASL]-[FY]-S-G-G-[LV]-D-T-[ST]. |
| Argininosuccinate synthase signature 2 | G-x-T-x-[KRM]-G-N-D-x(2)-R-F. |
| Aromatic amino acids permeases signature | I-G-[GA]-G-M-[LF]-[SA]-x-P-x(3)-[SA]-G-x(2)-F. |
| Arrestins signature | [FY]-R-Y-G-x-[DE](2)-x-[DE]-[LIVM](2)-G-[LIVM]-x-F-x-[RK]-[DEQ]-[LIVM]. |
| Arthropod CHH/MIH/GIH neurohormones family signature | [LIVM]-x(3)-C-[KR]-x-[DENGRH]-C-[FY]-x-[STN]-x(2)-F-x(2)-C. |
| Arthropod defensins signature | C-x(2,3)-[HNS]-C-x(3,4)-[GR]-{A}-x-[GRQ]-[GA]-x-C-x(4,7)-C-x-C. |
| Arthropod hemocyanins / insect LSPs signature 1 | Y-[FYW]-x-E-D-[LIVM]-x(2)-N-x(6)-H-x(3)-P. |
| Arthropod hemocyanins / insect LSPs signature 2 | T-x(2)-R-D-P-x-[FY]-[FYW]. |
| AsnC-type HTH domain signature | [GSTAP]-x(2)-[DNEQA]-[LIVM]-[GSA]-x(2)-[LIVMFYT]-[GAN]-[LIVMST]-[ST]-x(6)-R-[LIVT]-x(2)-[LIVM]-x(3)-G. |
| Asparaginase / glutaminase active site signature 1 | [LIVM]-x-{L}-T-G-G-T-[IV]-[AGS]. |
| Asparaginase / glutaminase active site signature 2 | [GA]-x-[LIVM]-x(2)-H-G-T-D-T-[LIVM]. |
| Aspartate and glutamate racemases signature 1 | [IVA]-[LIVM]-x-C-x(0,1)-N-[ST]-[MSA]-[STH]-[LIVFYSTANK]. |
| Aspartate and glutamate racemases signature 2 | [LIVM](2)-x-[AG]-C-T-[DEH]-[LIVMFY]-[PNGRS]-x-[LIVM]. |
| Aspartate and ornithine carbamoyltransferases signature | F-x-[EK]-x-S-[GT]-R-T. |
| Aspartate-semialdehyde dehydrogenase signature | [LIVM]-[SADN]-x(2)-C-x-R-[LIVM]-x(4)-[GSC]-H-[STA]. |
| Aspartic acid and asparagine hydroxylation site | C-x-[DN]-x(4)-[FY]-x-C-x-C. |
| Aspartokinase signature | [LIVM]-x-K-[FY]-G-G-[ST]-[SC]-[LIVM]. |
| Aspartyl proteases, omptin family signature 1 | W-T-D-x-S-x-H-P-x-T. |
| Aspartyl proteases, omptin family signature 2 | A-G-Y-Q-E-[ST]-R-[FYW]-S-[FYW]-[TN]-A-x-G-G-[ST]-Y. |
| Assassin bug toxin signature | C-[LI]-x(2)-G-[SA]-x-C-x-G-x(2)-K-x-C-C-x(4,5)-C-x(2)-Y-A-N-[RK]-C. |
| ATP P2X receptors signature | G-G-x-[LIVM]-G-[LIVM]-x-[IV]-x-W-x-C-[DN]-L-D-x(5)-C-x-P-x-Y-x-F. |
| ATP phosphoribosyltransferase signature | E-x(5)-[GND]-x-[SAG]-x(2)-[IV]-x-[DE]-[LIV]-x(2)-[ST]-G-x-T-[LMI]. |
| ATP synthase a subunit signature | [STAGN]-{E}-[STAG]-[LIVMF]-R-L-{LP}-[SAGV]-N-[LIVMT]. |
| ATP synthase alpha and beta subunits signature | P-[SAP]-[LIV]-[DNH]-{LKGN}-{F}-{S}-S-{DCPH}-S. |
| ATP synthase c subunit signature | [GSTA]-R-[NQ]-P-x(5)-{A}-x-{F}-x(2)-[LIVMFYW](2)-x(3)-[LIVMFYW]-x-[DE]. |
| ATP synthase delta (OSCP) subunit signature | [LIVM]-x-[LIVMFYT]-x(3)-[LIVMT]-[DENQK]-x-{G}-[LIVM]-x-[GSA]-G-[LIVMFYGA]-{S}-[LIVM]-[KRHENQ]-x-[GSEN]. |
| ATP synthase gamma subunit signature | [IV]-T-x-E-x(2)-[DE]-x(3)-G-A-x-[SAKR]. |
| ATP-citrate lyase / succinyl-CoA ligases family active site | G-x(2)-A-x(4,7)-[RQT]-[LIVMF]-G-H-[AS]-[GH]. |
| ATP-citrate lyase / succinyl-CoA ligases family signature 1 | S-[KR]-S-G-[GT]-[LIVM]-[GST]-x-[EQ]-x(8,10)-G-x(4)-[LIVM]-[GA]-[LIVM]-G-G-D. |
| ATP-citrate lyase / succinyl-CoA ligases family signature 3 | G-x-[IVT]-x(2)-[LIVMF]-x-[NAK]-[GS]-[GA]-G-[LMAI]-[STAV]-x(4)-[DN]-x-[LIVM]-x(3,4)-[GD]-[GREAK]. |
| ATP-dependent DNA ligase AMP-binding site | [EDQH]-{K}-K-{VEDI}-[DN]-G-{GLYN}-R-[GACIVM]. |
| ATP-dependent DNA ligase signature 2 | E-G-[LIVMA]-[LIVM]-[LIVMA]-[KR]-x(5,8)-[YW]-[QNEKTI]-x(2,6)-[KRH]-x(3,5)-K-[LIVMFY]-K. |
| ATP-dependent serine proteases, lon family, serine active site | D-G-[PD]-S-A-[GS]-[LIVMCA]-[TA]-[LIVM]. |
| ATP/GTP-binding site motif A (P-loop) | [AG]-x(4)-G-K-[ST]. |
| ATP:guanido phosphotransferases active site | C-P-x(0,1)-[ST]-N-[ILV]-G-T. |
| Autoinducers synthetase family signature | [LMFYA]-R-x(3)-F-x(2)-[KRQ]-x(2)-W-x-[LIVM]-x(6,9)-E-x-D-x-[FY]-D. |
| Avidin / Streptavidin family signature | [DENY]-x(2)-[KRI]-[STA]-x(2)-V-G-x-[DN]-x-[FW]-T-[KR]. |
| Bacterial chemotaxis sensory transducers signature | R-T-E-[EQ]-Q-x(2)-[SA]-[LIVM]-x-[EQ]-T-A-A-S-M-E-Q-L-T-A-T-V. |
| Bacterial export FHIPEP family signature | R-[LIVM]-[GSAT]-E-V-[GSAR]-A-R-F-[STAIV]-L-D-[GSA]-[LM]-P-G-K-Q-M-[GSA]-I-D-[GSA]-[DAE]. |
| Bacterial extracellular solute-binding proteins, family 1 signature | [GAP]-[LIVMFA]-[STAVDN]-x-{H}-x(2)-[GSAV]-[LIVMFY](2)-Y-[ND]-x(3)-[LIVMF]-x-[KNDE]. |
| Bacterial extracellular solute-binding proteins, family 3 signature | G-[FYIL]-[DE]-[LIVMT]-[DE]-[LIVMF]-{PS}-{YG}-x-[LIVMA]-[VAGC]-{TPRG}-{GL}-[LIVMAGN]. |
| Bacterial extracellular solute-binding proteins, family 5 signature | [AG]-x(6,7)-[DNEG]-x(2)-[STAIVE]-[LIVMFYWA]-x-[LIVMFY]-x-[LIVM]-[KR]-[KRHDE]-[GDN]-[LIVMA]-[KNGSP]-[FW]. |
| Bacterial histone-like DNA-binding proteins signature | [GSK]-F-x(2)-[LIVMF]-x(4)-[RKEQA]-x(2)-[RST]-x(1,2)-[GA]-x-[KN]-P-x-[TN]. |
| Bacterial ice-nucleation proteins octamer repeat | A-G-Y-G-S-T-x-T. |
| Bacterial luciferase subunits signature | [GA]-[LIVM]-P-[LIVM]-x-[LIVMFY]-x-W-x(6)-[RK]-x(6)-Y-x(3)-[AR]. |
| Bacterial microcompartiments proteins signature | D-x(0,1)-M-x-K-[SAG](2)-x-[IV]-x-[LIVM]-[LIVMA]-[GCSY]-x(4)-[GDE]-[SGPDR]-[GA]. |
| Bacterial quinoprotein dehydrogenases signature 1 | [DEN]-[WV]-x(3)-G-[RKNM]-x(6)-[FYW]-[SV]-x(4)-[LIVM]-N-x(2)-N-V-x(2)-L-[RKT]. |
| Bacterial quinoprotein dehydrogenases signature 2 | W-x(4)-[YF]-D-x(3)-[DN]-[LIVMFYT]-[LIVMFY](3)-x(2)-G-x(2)-[STAG]-[PVT]. |
| Bacterial regulatory proteins, araC family signature | [KRQ]-[LIVMA]-x(2)-[GSTALIV]-{FYWPGDN}-x(2)-[LIVMSA]-x(4,9)-[LIVMF]-x-{PLH}-[LIVMSTA]-[GSTACIL]-{GPK}-{F}-x-[GANQRF]-[LIVMFY]-x(4,5)-[LFY]-x(3)-[FYIVA]-{FYWHCM}-{PGVI}-x(2)-[GSADENQKR]-x-[NSTAPKL]-[PA. |
| Bacterial regulatory proteins, arsR family signature | C-x(2)-D-[LIVM]-x(6)-[ST]-x(4)-S-[HYR]-[HQ]. |
| Bacterial rhodopsins retinal binding site | [FYIV]-{ND}-[FYVG]-[LIVM]-D-[LIVMF]-x-[STA]-K-x-{K}-[FY]. |
| Bacterial rhodopsins signature 1 | R-Y-x-[DT]-W-x-[LIVMF]-[ST]-[TV]-P-[LIVM]-[LIVMNQ]-[LIVM]. |
| Bacterial ribonuclease P protein component signature | [LIVMFYSNAD]-x(2)-A-x(2)-R-[NH]-[KRQLYAT]-[LIVMFSA]-[KRA]-R-x-[LIVMTA]-[KR]. |
| Bacterial ring hydroxylating dioxygenases alpha-subunit signature | C-x-H-R-[GAR]-x(7,8)-[GEKVI]-[NERAQ]-x(4,5)-C-x-[FY]-H. |
| Bacterial type II secretion system protein C signature | P-x(6)-F-x(4)-[LF]-x(3)-D-[LIVM]-A-[LIVM]-x-[LIVM]-N-x-[LIVMQ]-x-[LF]. |
| Bacterial type II secretion system protein D signature | [GRH]-[DEQKG]-[STVM]-[LIVMA](3)-[GA]-G-[LIVMFY]-x(11)-[LIVM]-P-[LIVMFYWGS]-[LIVMF]-[GSAE]-x-[LIVMS]-P-[LIVMFYW]-[LIVMFYWS]-x(2,3)-[LV]-[FK]. |
| Bacterial type II secretion system protein E signature | [LIVM]-R-x(2)-P-D-x-[LIVM](3)-G-E-[LIVM]-R-D. |
| Bacterial type II secretion system protein F signature | [KRQ]-[LIVMAW]-x(2)-[SAIV]-[LIVM]-x-[TY]-P-x(2)-[LIVM]-x(3)-[STAGV]-x(6)-[LMY]-x(3)-[LIVMF](2)-P. |
| Bacterial type II secretion system protein N signature | G-T-L-W-x-G-x(11)-L-x(4)-W. |
| Bacterial-type phytoene dehydrogenase signature | [NG]-x-[FYWV]-[LIVMF]-x-G-[AGC]-[GS]-[TA]-[HQT]-P-G-[STAV]-G-[LIVM]-x(5)-[GS]. |
| Bacteriocin class IIa family signature | Y-G-N-G-[VL]-x-C-x(4)-C. |
| Bacterioferritin signature | |
| Bacteriophage-type RNA polymerase family active site signature 1 | P-[LIVM]-x(2)-D-[GA]-[ST]-[AC]-[SN]-[GA]-[LIVMFY]-Q. |
| Bacteriophage-type RNA polymerase family active site signature 2 | [LIVMF]-x-R-x(3)-K-x(2)-[LIVMF]-M-[PT]-x(2)-Y. |
| Band 7 protein family signature | R-x(2)-[LIV]-[SAN]-x(6)-[LIV]-D-x(2)-T-x(2)-W-G-[LIVT]-[KRH]-[LIV]-x-[KRA]-[LIV]-E-[LIV]-[KRQ]. |
| Barwin domain signature 1 | C-G-[KR]-C-L-x-V-x-N. |
| Barwin domain signature 2 | V-[DN]-Y-[EQD]-F-V-[DN]-C. |
| Basic-leucine zipper (bZIP) domain signature | [KR]-x(1,3)-[RKSAQ]-N-{VL}-x-[SAQ](2)-{L}-[RKTAENQ]-x-R-{S}-[RK]. |
| Bax inhibitor-1 family signature | G-x(2)-[LIVM]-[GC]-P-x-[LI]-x(4)-[SAGDT]-x(4,6)-[LIVM](2)-x(2)-A-x(2)-[MG]-T-x-[LIVM]-x-F. |
| BCCT family of transporters signature | [GSDNA]-W-T-[LIVM]-x-[FY]-W-x-W-W. |
| Beta-amylase active site 1 | H-x-C-G-G-N-V-G-D. |
| Beta-amylase active site 2 | G-x-[SA]-G-E-[LIVM]-R-Y-P-S-Y. |
| Beta-eliminating lyases pyridoxal-phosphate attachment site | [YV]-x-D-x(3)-M-S-[GA]-K-K-D-x-[LIVMF]-[LIVMAG]-x-[LIVM]-G-G. |
| Beta-ketoacyl synthases active site | G-{A}-{KGR}-x(2)-[LIVMFTAP]-{R}-x-[AGC]-C-[STA](2)-[STAG]-x(2)-{LI}-[LIVMF]. |
| Beta-lactamase class-A active site | [FY]-x-[LIVMFY]-{E}-S-[TV]-x-K-x(3)-{T}-[AGLM]-{D}-{KA}-[LC]. |
| Beta-lactamase class-C active site | [FY]-E-[LIVM]-G-S-[LIVMG]-[SA]-K. |
| Beta-lactamase class-D active site | [PA]-x-S-[ST]-F-K-[LIV]-[PALV]-x-[STA]-[LI]. |
| Beta-lactamases class B signature 1 | [LI]-x-[STN]-[HN]-x-H-[GSTAD]-D-x(2)-G-[GP]-x(7,8)-[GS]. |
| Beta-lactamases class B signature 2 | P-x(3)-[LIVM](2)-x-G-x-C-[LIVMF](2)-K. |
| Biopterin-dependent aromatic amino acid hydroxylases signature | P-D-x(2)-H-[DE]-[LIVF]-[LIVMFY]-G-H-[LIVMC]-[PA]. |
| Biotin-requiring enzymes attachment site | [GDN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LVMAT]-x(3)-[LIVM]-x-[SAV]. |
| BIR repeat | [HKEPILVY]-x(2)-R-x(3,7)-[FYW]-x(11,14)-[STAN]-G-[LMF]-x-[FYHDA]-x(4)-[DESL]-x(2,3)-C-x(2)-C-x(6)-[WA]-x(9)-H-x(4)-[PRSD]-x-C-x(2)-[LIVMA]. |
| Bombesin-like peptides family signature | W-A-x-G-[SH]-[LF]-M. |
| Bowman-Birk serine protease inhibitors family signature | C-x(5,6)-[DENQKRHSTA]-C-[PASTDH]-[PASTDK]-[ASTDV]-C-[NDEKS]-[DEKRHSTA]-C. |
| Bromodomain signature | [STANVFHG]-x(2)-[FAS]-x(4)-[DNSPAKT]-x(0,7)-[DENQTFG]-Y-[HFYLRKT]-x(2)-[LIVMFY]-x(3)-[LIVM]-x(4)-[LIVM]-x(6,10)-Y-x(12,13)-[LIVM]-x(2)-N-[SACF]-x(2)-[FY]. |
| BTG family signature 1 | Y-x(2)-[HP]-W-[FYH]-[APS]-[DE]-x-P-x-K-G-x-[GA]-[FY]-R-C-[IV]-[RH]-[IV]. |
| BTG family signature 2 | [LV]-P-x-[DE]-[LM]-[ST]-[LIVM]-W-[IV]-D-P-x-E-V-[SC]-x-[RQ]-x-G-[EK]. |
| C-5 cytosine-specific DNA methylases active site | [DENKS]-x-[FLIV]-x(2)-[GSTC]-x-P-C-x-{V}-[FYWLIM]-S. |
