Protein domains in Prosite database.
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| Hydroxymethylglutaryl-coenzyme A reductases signature 3 | A-[LIVM]-x-[STAN]-x(2)-[LI]-x-[KRNQ]-[GSA]-H-[LM]-x-[FYLH]. |
| Hydroxymethylglutaryl-coenzyme A synthase active site | N-x-[DN]-[IV]-E-G-[IV]-D-x(2)-N-A-C-[FY]-x-G. |
| Hypothetical cof family signature 1 | [LIVFYAN]-[LIVMFA]-x(2)-D-[LIVMF]-[ND]-G-T-[LIV]-[LVY]-[STANLM]. |
| Hypothetical cof family signature 2 | [LIVMFC]-G-D-[GSANQ]-x-N-D-x(3)-[LIMFY]-x(2)-[AV]-x(2)-[GSCP]-x(2)-[LMP]-x(2)-[GAS]. |
| Hypothetical hesB/yadR/yfhF family signature | [FQ]-x-[LIVMFY]-x-[NH]-[PGT]-[NSKQR]-x(4)-C-x-C-[GSN]-x-S-F. |
| I-superfamily conotoxin signature | C-{C}(6)-C-{C}(5)-C-C-x(1,3)-C-C-x(2,4)-C-x(3,10)-C. |
| Imidazoleglycerol-phosphate dehydratase signature 1 | [LIVMY]-[DE]-x-H-H-x(2)-E-x(2)-[GCA]-[LIVM]-[STAVCL]-[LIVMF]. |
| Imidazoleglycerol-phosphate dehydratase signature 2 | [GW]-x-[DNIE]-x-H-H-x(2)-E-[STAGC]-x-[VMFYHS]-K. |
| Immunoglobulins and major histocompatibility complex proteins signature | [FY]-{L}-C-{PGAD}-[VA]-{LC}-H. |
| IMP dehydrogenase / GMP reductase signature | [LIVMT]-[RK]-[LIVM]-G-[LIVM]-G-x-G-[SRK]-[LIVMAT]-C-x-T. |
| Indole-3-glycerol phosphate synthase signature | [LIVMFY]-[LIVMC]-x-E-[LIVMFYC]-K-[KRSPQV]-[STAHKRYC]-S-P-[STRK]-x(3,7)-[LIVMFYST]. |
| Indoleamine 2,3-dioxygenase signature 1 | G-G-S-[AN]-[GA]-Q-S-S-x(2)-Q. |
| Indoleamine 2,3-dioxygenase signature 2 | [FY]-L-[DQ]-[DE]-[LIVM]-x(2)-Y-M-x(3)-H-[KR]. |
| Initiation factor 2 signature | [GLES]-x-[LIVM]-x(2)-L-[KR]-[KRHNS]-x-K-x(5)-[LIVM]-x(2)-[GNKADS]-x-[DEN]-[CRG]-[GI]. |
| Initiation factor 3 signature | [KR]-[LIVM](2)-[DN]-[FY]-[GSTN]-[KR]-[LIVMFYS]-x-[FY]-[DEQTAHI]-x(2)-[KRQ]. |
| Inorganic pyrophosphatase signature | D-[SGDN]-D-[PE]-[LIVMF]-D-[LIVMGAC]. |
| Inosine-uridine preferring nucleoside hydrolase family signature | D-x-D-[PT]-[GA]-x-D-D-[TAV]-[VI]-A. |
| Inositol monophosphatase family signature 1 | [FWV]-x(0,1)-[LIVM]-D-P-[LIVM]-D-[SG]-[ST]-x(2)-[FYA]-x(0,1)-[HKRNSTY]. |
| Inositol monophosphatase family signature 2 | [WYV]-D-x-[AC]-[GSA]-[GSAPV]-x-[LIVFACP]-[LIVM]-[LIVAC]-x(3)-[GH]-[GA]. |
| Insulin family signature | C-C-{P}-{P}-x-C-[STDNEKPI]-x(3)-[LIVMFS]-x(3)-C. |
| Insulin-like growth factor binding proteins signature | [GP]-C-[GSET]-[CE]-[CA]-x(2)-C-[ALP]-x(6)-C. |
| Insulinase family, zinc-binding region signature | G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-[LMFAT]-x-[LFSTH]-x-[GSTAN]-[GST]. |
| Integrins alpha chain signature | [FYWS]-[RK]-x-G-F-F-x-R. |
| Integrins beta chain cysteine-rich domain signature | C-x-[GNQ]-x(1,3)-G-x-C-x-C-x(2)-C-x-C. |
| Interferon alpha, beta and delta family signature | [FYH]-[FY]-x-[GNRCDS]-[LIVM]-x(2)-[FYL]-L-x(7)-[CY]-[AT]-W. |
| Interleukin-1 signature | [FC]-x-S-[ASLV]-x(2)-P-x(2)-[FYLIV]-[LI]-[SCA]-T-x(7)-[LIVM]. |
| Interleukin-10 family signature | [KQS]-x(4)-C-[QYCS]-x(4)-[LIVM](2)-x-[FLR]-[FYT]-[LMVR]-x-[DERTI]-[IV]-[LMF]. |
| Interleukin-2 signature | T-E-[LF]-x(2)-L-x-C-L-x(2)-E-L. |
| Interleukin-6 / G-CSF / MGF signature | C-x(9)-C-x(6)-G-L-x(2)-[FY]-x(3)-L. |
| Interleukin-7 and -9 signature | N-x-[LAP]-[SCT]-F-L-K-x-L-L. |
| Interleukins -4 and -13 signature | [LI]-x-E-[LIVM](2)-x(4,5)-[LIVM]-[TL]-x(5,7)-C-x(4)-[IVA]-x-[DNS]-[LIVMA]. |
| Intermediate filaments signature | [IV]-{K}-[TACI]-Y-[RKH]-{E}-[LM]-L-[DE]. |
| Intradiol ring-cleavage dioxygenases signature | [LIVMF]-x-G-x-[LIVM]-x(4)-[GS]-x(2)-[LIVMA]-x(4)-[LIVM]-[DE]-[LIVMFYC]-x(6)-G-x-[FY]. |
| Involucrin signature | |
| Iodothyronine deiodinases active site | R-P-L-[IV]-x-[NS]-F-G-S-[CA]-[TS]-C-P-x-F. |
| Iron-containing alcohol dehydrogenases signature 1 | [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-x(2)-D-[TAIVM]-[LIVMF]-x(4)-E. |
| Iron-containing alcohol dehydrogenases signature 2 | [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-[GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]. |
| Isocitrate and isopropylmalate dehydrogenases signature | [NSK]-[LIMYTV]-[FYDNH]-[GEA]-[DNGSTY]-[IMVYL]-x-[STGDN]-[DN]-x(1,2)-[SGAP]-x(3,4)-[GE]-[STG]-[LIVMPA]-[GA]-[LIVMF]. |
| Isocitrate lyase signature | K-[KR]-C-G-H-[LMQR]. |
| Isopenicillin N synthetase signature 1 | [RK]-x-[STA]-x(2)-S-x-C-Y-[SL]. |
| Isopenicillin N synthetase signature 2 | [LIVM](2)-x-C-G-[STA]-x(2)-[STAG]-x(2)-T-x-[DNG]. |
| Janus-faced atracotoxin (J-ACTX) family signature | C-{C}(6)-C-x(2)-C-C-x-C-C-x(4)-C-x(9,10)-C. |
| Kazal serine protease inhibitors family signature | C-x(4)-{C}-x(2)-C-x-{A}-x(4)-Y-x(3)-C-x(2,3)-C. |
| KDPG and KHG aldolases active site | G-[LIVM]-x(3)-E-[LIV]-T-[LF]-R. |
| KDPG and KHG aldolases Schiff-base forming residue | G-x(3)-[LIVMF]-K-[LF]-F-P-[SA]-x(3)-G. |
| Kinesin light chain repeat | [DEQR]-A-L-x(3)-[GEQ]-x(3)-G-x-[DNS]-x-P-x-V-A-x(3)-N-x-L-[AS]-x(5)-[QR]-x-[KR]-[FY]-x(2)-[AV]-x(4)-[HKNQ]. |
| Kinesin motor domain signature | [GSAT]-[KRHPSTQVME]-[LIVMFY]-x-[LIVMF]-[IVC]-[DN]-[LS]-[AH]-G-[SAN]-E. |
| Kringle domain signature | [FY]-C-[RH]-[NS]-x(7,8)-[WY]-C. |
| L-lactate dehydrogenase active site | [LIVMA]-G-[EQ]-H-G-[DN]-[ST]. |
| LacI-type HTH domain signature | [LIVM]-x-[DE]-[LIVM]-A-x(2)-[STAGV]-x-V-[GSTP]-x(2)-[STAG]-[LIVMA]-x(2)-[LIVMFYAN]-[LIVMC]. |
| LacY family proton/sugar symporters signature 1 | G-[LIVM](2)-x-D-[RK]-L-G-L-[RK](2)-x-[LIVM](2)-W. |
| LacY family proton/sugar symporters signature 2 | P-x-[LIVMF](2)-N-R-[LIVM]-G-x-K-N-[STA]-[LIVM](3). |
| Lambdoid phages regulatory protein CIII signature | E-S-x-L-x-R-x(2)-[KR]-x-L-x(4)-[KR](2)-x(2)-[DE]-x-L. |
| Laminin-type EGF-like (LE) domain signature | C-x(1,2)-C-x(5)-G-x(2)-C-x(2)-C-x(3,4)-[FYW]-x(3,15)-C. |
| LAMP glycoproteins transmembrane and cytoplasmic domain signature | C-x(2)-D-x(3,4)-[LIVM](2)-P-[LIVM]-x-[LIVM]-G-x(2)-[LIVM]-x-G-[LIVM](2)-x-[LIVM](4)-A-[FY]-x-[LIVM]-x(2)-[KR]-[RH]-x(1,2)-[STAG](2)-Y-[EQ]. |
| Large-conductance mechanosensitive channels mscL family signature | [KR]-G-N-[LIVM](2)-D-[LIVM]-A-[LIVM]-[GA]-[LIVM](3)-G. |
| LBP / BPI / CETP family signature | [PA]-[GA]-[LIVMC]-x(2)-R-[IV]-[ST]-x(3)-L-x(5)-[EQAV]-x(4)-[LIVM]-[EQK]-x(8)-P. |
| LDL-receptor class A (LDLRA) domain signature | C-[VILMA]-x(5,6)-C-[DNH]-x(3)-[DENQHT]-C-x(3,4)-[STADEW]-[DEH]-[DE]-x(1,5)-C. |
| Legume lectins alpha-chain signature | [LIV]-{LA}-[EDQ]-[FYWKR]-V-{VF}-[LIVF]-G-[LF]-[ST]. |
| Legume lectins beta-chain signature | [LIV]-[STAG]-V-[DEQV]-[FLI]-D-[ST]. |
| Leucine zipper pattern | L-x(6)-L-x(6)-L-x(6)-L. |
| LIF / OSM family signature | [PST]-x(4)-F-[NQ]-x-K-x(3)-C-x-[LF]-L-x(2)-Y-[HK]. |
| LIM zinc-binding domain signature | C-x(2)-C-x(15,21)-[FYWHPCR]-H-x(2)-[CH]-x(2)-C-x(2)-C-x(3)-[LIVMF]. |
| Link domain signature | C-x(15)-A-x(3,4)-[GK]-x(3)-C-x(2)-G-x(8,9)-P-x(7)-C. |
| Lipases, serine active site | [LIV]-{KG}-[LIVFY]-[LIVMST]-G-[HYWV]-S-{YAG}-G-[GSTAC]. |
| Lipoate-protein ligase B signature | R-G-G-x(2)-T-[FYWCAH]-H-x(2)-[GHS]-Q-x-[LIVMT]-x-Y. |
| Lipocalin signature | [DENG]-{A}-[DENQGSTARK]-x(0,2)-[DENQARK]-[LIVFY]-{CP}-G-{C}-W-[FYWLRH]-{D}-[LIVMTA]. |
| Lipolytic enzymes "G-D-S-L" family, serine active site | [LIVMFYAG](4)-G-D-S-[LIVM]-x(1,2)-[TAG]-G. |
| Lipolytic enzymes "G-D-X-G" family, putative histidine active site | [LIVMF](2)-x-[LIVMF]-H-G-G-[SAG]-[FYW]-x(3)-[STDN]-x(1,2)-[STYA]-[HAGFT]. |
| Lipolytic enzymes "G-D-X-G" family, putative serine active site | [LIVM]-x-[LIVMF]-[SA]-G-D-S-[CAS]-G-[GA]-x-[LI]-[CAVT]. |
| Lipoxygenases iron-binding region signature 1 | [HQ]-[EQ]-x(3)-H-x-[LMA]-[NEQHRCS]-[GSTA]-H-[LIVMSTAC](2)-x-E. |
| Lipoxygenases iron-binding region signature 2 | [LIVMACST]-H-P-[LIVM]-x-[KRQV]-[LIVMF](2)-x-[AP]-H. |
| Long hematopoietin receptor, gp130 family signature | N-x(4)-S-x(28,35)-[LVIM]-x-W-x(0,3)-P-x(5,9)-[YF]-x(1,2)-[VILM]-x-W. |
| Long hematopoietin receptor, single chain family signature | [LIV]-x-[LIV]-x-W-x(12,16)-Y-[EQ]-[LIV]-x(25,27)-L-x(10)-[RKH]-x-[RKH]-x(5,9)-[FYW]-x(2)-[FYW]-x(5)-[LIV]. |
| Long hematopoietin receptor, soluble alpha chains family signature | [LIV]-x-P-D-P(2)-x(2)-[LIV]-x(8,11)-[LVAM]-x(3)-W-x(2)-P-x-[ST]-W-x(4,6)-[FY]-x-L-x-[FY]-x-[LVI]. |
| LuxR-type HTH domain signature | [GDC]-x(2)-[NSTAVY]-x(2)-[IV]-[GSTA]-x(2)-[LIVMFYWCT]-x-[LIVMFYWCR]-x(3)-[NST]-[LIVM]-x(2)-{T}-x(2)-[NRHSA]-[LIVMSTA]-x(2)-[KR]. |
| Ly-6 / u-PAR domain signature | [EQR]-C-[LIVMFYAH]-x-C-x(5,8)-C-x(3,8)-[EDNQSTV]-C-{C}-x(5)-C-x(12,24)-C. |
| Lysosome-associated membrane glycoproteins duplicated domain signature | [STA]-C-[LIVM]-[LIVMFYW]-A-x-[LIVMFYW]-x(3)-[LIVMFYW]-x(3)-Y. |
| Lysyl hydroxylase signature | P-H-H-D-[SA]-S-T-F. |
| Lysyl oxidase putative copper-binding region signature | W-x-W-H-x-C-H-x-H-[YN]-H-S-[MI]-[DE]. |
| Macrophage migration inhibitory factor family signature | [DE]-P-[CLV]-[APT]-x(3)-[LIVM]-x-S-[IS]-[GT]-x-[LIVM]-[GST]. |
| MADS-box domain signature | [RGS]-x-[RKS]-x(5)-[IL]-x-[DNGSK]-x(3)-[KR]-x(2)-T-[FY]-x-[RK](3)-x(2)-[LIVM]-x-[KE]-K-[AT]-x-[EQ]-[LIVM]-[STA]-x-L-x(4)-[LIVM]-x-[LIVM]-[LIVMT]-[LIVM]-x(6)-[LIVMFC]-x(2)-[FYLS]. |
| Malate dehydrogenase active site signature | [LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY]. |
| Malate synthase signature | [KR]-[DENQ]-[HN]-x(2)-G-L-N-x-G-x-W-D-Y-[LIVM]-F. |
| Malic enzymes signature | [FM]-x-[DV]-D-x(2)-[GS]-T-[GSA]-x-[IV]-x-[LIVMAT]-[GAST]-[GASTC]-[LIVMFA]-[LIVMFY]. |
| MAM domain signature | [GE]-x-[LIVMFY](2)-x(3)-[STA]-x(10,11)-[LV]-x(4)-[LIVMF]-x(6,7)-C-[LIVM]-x-F-x-[LIVMFY]-x(3)-[GSC]. |
| Mammalian defensins signature | C-x-C-x(3,5)-C-x(7)-G-x-C-x(9)-C-C. |
| Mandelate racemase / muconate lactonizing enzyme family signature 1 | [AT]-x-[SAGCN]-[SAGC]-[LIVM]-[DEQ]-x-A-[LA]-x-[DE]-[LIA]-x-[GA]-[KRQ]-x(4)-[PSA]-[LIV]-x(2)-L-[LIVMF]-G. |
| Mandelate racemase / muconate lactonizing enzyme family signature 2 | [LIVF]-x(2)-D-x-[NH]-x(7)-[ACL]-x(6)-[LIVMF]-x(7)-[LIVM]-E-[DENQ]-P. |
| Manganese and iron superoxide dismutases signature | D-x-[WF]-E-H-[STA]-[FY](2). |
| Mannitol dehydrogenases signature | [LIVMY]-x-[FS]-x(2)-[STAGCV]-x-V-D-R-[IV]-x-[PS]. |
| MAP kinase signature | F-x(10)-R-E-x(72,86)-R-D-x-K-x(9)-[CS]. |
| MARCKS family phosphorylation site domain | E-T-P-K(5)-x(0,1)-F-S-F-K-K-x-F-K-L-S-G-x-S-F-K-[KR]-[NS]-[KR]-K-E. |
| MARCKS family signature 1 | G-Q-E-N-G-H-V-[KR]. |
| MarR-type HTH domain signature | [STNAQ]-[LIAMV]-x(0,1)-[RNGSYKE]-x(4,5)-[LM]-[EIVLA]-x(2)-[GESD]-[LFYWHA]-[LIVC]-x(7)-[DNS]-[RKQG]-[RK]-x(6)-[TS]-x(2)-[GAS]. |
| Matrixins cysteine switch | P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]. |
| MCM family signature | G-[IVT]-[LVAC](2)-[IVT]-D-[DE]-[FL]-[DNST]. |
| Membrane attack complex components / perforin signature | Y-x(6)-[FY]-G-T-H-[FY]. |
| MerR-type HTH domain signature | [GSA]-x-[LIVMFA]-[ASM]-x(2)-[STACLIV]-[GSDENQR]-[LIVC]-[STANHK]-x(3)-[LIVM]-[RHF]-x-[YW]-[DEQ]-x(2,3)-[GHDNQ]-[LIVMF](2). |
| Methionine aminopeptidase subfamily 1 signature | [MFY]-x-G-H-G-[LIVMC]-[GSHN]-x(3)-H-x(4)-[LIVM]-x(1,2)-[HN]-[YWVHF]. |
