Protein domains in Prosite database.
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| Cyclin-dependent kinases regulatory subunits signature 1 | Y-S-x-[KR]-Y-x-[DE](2)-x-[FY]-E-Y-R-H-V-x-[LV]-[PT]-[KRP]. |
| Cyclin-dependent kinases regulatory subunits signature 2 | H-x-P-E-x-H-[IV]-L-L-F-[KR]. |
| Cyclins signature | R-x(2)-[LIVMSA]-x(2)-[FYWS]-[LIVM]-x(8)-[LIVMFC]-x(4)-[LIVMFYA]-x(2)-[STAGC]-[LIVMFYQ]-x-[LIVMFYC]-[LIVMFY]-D-[RKH]-[LIVMFYW]. |
| Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature | [FY]-x(2)-[STCNLVA]-x-[FV]-H-[RH]-[LIVMNS]-[LIVM]-x(2)-F-[LIVM]-x-Q-[AGFT]-G. |
| Cyclotides bracelet subfamily signature | C-x(0,1)-[ES]-S-C-[AV]-[MFYW]-I-[PS]-x(0,1)-C. |
| Cyclotides Moebius subfamily signature | C-[GA]-E-[ST]-C-[FTV]-[GLTI]-G-[TSK]-C. |
| Cys/Met metabolism enzymes pyridoxal-phosphate attachment site | [DQ]-[LIVMFY]-x(3)-[STAGCN]-[STAGCIL]-T-K-[FYWQI]-[LIVMF]-x-G-[HQD]-[SGNH]. |
| Cysteine proteases inhibitors signature | [GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-{S}-[LIVMFYA]-[DENQKRHSIV]. |
| Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site | K-x-E-x(3,4)-[PAF]-[STAGC]-x-S-[IVAPM]-K-x-R-x-[STAG]-x(2)-[LIVM]. |
| Cytidine and deoxycytidylate deaminases zinc-binding region signature | [CH]-[AGV]-E-x(2)-[LIVMFGAT]-[LIVM]-x(17,33)-P-C-x(2,8)-C-x(3)-[LIVM]. |
| Cytochrome b5 family, heme-binding domain signature | [FY]-[LIVMK]-{I}-{Q}-H-P-[GA]-G. |
| Cytochrome b559 subunits heme-binding site signature | [LIV]-x-[ST]-[LIVF]-R-[FYW]-x(2)-[IVL]-H-[STGAV]-[LIV]-[STGA]-[IV]-P. |
| Cytochrome c and c1 heme lyases signature 1 | H-N-x(2)-N-E-x(2)-W-[NQKRS]-x(4)-W-E. |
| Cytochrome c and c1 heme lyases signature 2 | P-F-D-R-H-D-W. |
| Cytochrome c oxidase subunit Vb, zinc binding region signature | [LIVM](2)-[FYW]-x(10)-C-x(2)-C-G-x(2)-[FY]-K-L. |
| Cytochrome c oxidase subunit VIa signature | [LIV]-R-x-K-x-[FYW]-x-W-[GS]-D-G-x-[KH]-[ST]-x-F-x-N. |
| Cytochrome P450 cysteine heme-iron ligand signature | [FW]-[SGNH]-x-[GD]-{F}-[RKHPT]-{P}-C-[LIVMFAP]-[GAD]. |
| Cytosol aminopeptidase signature | [NS]-[TS]-D-A-E-G-R-[LVMI]. |
| Cytosolic fatty-acid binding proteins signature | [GSAIVK]-{FE}-[FYW]-x-[LIVMF]-x(2)-{K}-x-[NHG]-[FY]-[DE]-x-[LIVMFY]-[LIVM]-{N}-{G}-[LIVMAKR]. |
| D-alanine--D-alanine ligase signature 1 | H-[GN]-x(2)-[GC]-E-[DNT]-G-x-[LIVMAFT]-[QSAPH]-[GSA]. |
| D-alanine--D-alanine ligase signature 2 | [LIVAMSFT]-x(3)-[GAHDVSI]-x-[GSAIVCT]-R-[LIVMCAFST]-[DE]-[LIVMFAYGT]-[LIVMFAR]-x(7,12)-[LIVWCAF]-x-[EK]-[LIVAPMT]-N-[STPA]-x-P-[GA]. |
| D-amino acid oxidases signature | [LIVM](2)-H-[NHA]-Y-G-x-[GSA](2)-x-G-x(5)-G-x-A. |
| D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature | [LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-G-x(13,14)-[LIVMFT]-{A}-x-[FYWCTH]-[DNSTK]. |
| D-isomer specific 2-hydroxyacid dehydrogenases signature 2 | [LIVMFYWA]-[LIVFYWC]-x(2)-[SAC]-[DNQHR]-[IVFA]-[LIVF]-x-[LIVF]-[HNI]-x-P-x(4)-[STN]-x(2)-[LIVMF]-x-[GSDN]. |
| D-isomer specific 2-hydroxyacid dehydrogenases signature 3 | [LMFATCYV]-[KPQNHAR]-x-[GSTDNK]-x-[LIVMFYWRC]-[LIVMFYW](2)-N-x-[STAGC]-R-[GP]-x-[LIVH]-[LIVMCT]-[DNVE]. |
| Dbl homology (DH) domain signature | [LM]-x(2)-[LIVMFYWGS]-[LI]-x(2)-[PEQ]-[LIVMRF]-x(2)-[LIVM]-x-[KRS]-x(2)-[LT]-x-[LIVM]-x-[DEQN]-[LIVM]-x(3)-[STM]. |
| DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site | S-[LIVMFYW]-x-{KG}-x(3)-K-[LIVMFYWGH]-[LIVMFYWG]-x-{R}-x-[LIVMFYW]-{V}-[CA]-x(2)-[LIVMFYWQ]-{K}-x-[RK]. |
| DEAD-box subfamily ATP-dependent helicases signature | [LIVMF](2)-D-E-A-D-[RKEN]-x-[LIVMFYGSTN]. |
| DEAH-box subfamily ATP-dependent helicases signature | [GSAH]-x-[LIVMF](3)-D-E-[ALIV]-H-[NECR]. |
| Dehydrins signature 1 | S(4)-[SD]-[DE]-x-[DE]-[GVE]-x(1,7)-[GE]-x(0,2)-[KR](4). |
| Dehydrins signature 2 | [KR]-[LIM]-K-[DE]-K-[LIM]-P-G. |
| Dehydroquinase class I active site | D-[LIVM]-[DE]-[LIVMN]-x(18,20)-[LIVM](2)-x-[SC]-[NHY]-H-[DN]. |
| Dehydroquinase class II signature | [LIVM]-[NQHS]-G-P-N-[LVI]-x(2)-[LT]-G-x-R-[QED]-x(3)-[FY]-G. |
| Delta 1-pyrroline-5-carboxylate reductase signature | [PALF]-x(2,3)-[LIV]-x(3)-[LIVM]-[STAC]-[STV]-x-[GANK]-G-x-T-x(2)-[AG]-[LIV]-x(2)-[LMF]-[DENQK]. |
| Delta-aminolevulinic acid dehydratase active site | G-x-D-x-[LIVM](2)-[IV]-K-P-[GSA]-x(2)-Y. |
| Delta-atracotoxin (ACTX) family signature | C-x(5)-W-C-x(4)-D-C-C-C-x(3)-C-x(2)-A-W-Y-x(5)-C-x(10,11)-C. |
| Delta-conotoxin family signature | C-x(2)-[EPSAGT]-x(3)-C-[GSNDL]-x(0,3)-[PILV]-x-[FPNDSG]-[GQ]-x-C-C-x(3,4)-C-[FLVIA]-x(1,2)-[FVIWA]-C. |
| DeoR-type HTH domain signature | R-{G}-x(2)-[LIVM]-x(3)-[LIVM]-x(16,17)-[STA]-x(2)-T-[LIVMA]-[RH]-[KRNAQ]-D-[LIVMF]. |
| Deoxyribonuclease I signature 1 | [LIVM](2)-[AP]-[LQ]-H-[STA]-[STAE]-P-x(5)-E-[LIVM]-[DN]-x-L-x-[DE]-V. |
| Deoxyribonuclease I signature 2 | G-D-F-N-A-x-C-[SAK]. |
| Diaminopimelate epimerase signature | N-x-[DN]-[GS]-[SENGFT]-x(4)-C-[GI]-N-[GA]-x-R. |
| Dihydrodipicolinate reductase signature | [ERND]-[IVL]-x-[ED]-x-H-x(3)-K-x-[DE]-x(2)-S-[GA]-[TAS]-[ALCGS]. |
| Dihydrodipicolinate synthetase signature 1 | [GSA]-[LIVM]-[LIVMFY]-x(2)-G-[ST]-[TG]-G-E-[GASNF]-x(6)-[EQ]. |
| Dihydrodipicolinate synthetase signature 2 | Y-[DNSAH]-[LIVMFAN]-P-x(2)-[STAV]-x(2,3)-[LIVMFT]-x(13,14)-[LIVMCF]-x-[SGA]-[LIVMFNS]-K-[DEQAFYH]-[STACI]. |
| Dihydrofolate reductase signature | [LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-[FYIV]-x(3)-[STIQ]. |
| Dihydroorotase signature 1 | D-[LIVMFYWSAP]-H-[LIVA]-H-[LIVF]-[RN]-x-[PGANF]. |
| Dihydroorotase signature 2 | [GAVS]-[ST]-D-x-A-P-H-x(4)-K. |
| Dihydroorotate dehydrogenase signature 1 | [GSA]-x(4)-[GK]-[GSTA]-[LIVFSTA]-[GST]-x(3)-[NQRK]-x-G-[NHY]-x(2)-P-[RTV]. |
| Dihydroorotate dehydrogenase signature 2 | [LIVM](2)-[GSA]-x-G-G-[IV]-x-[STGDN]-x(3)-[ACV]-x(2)-{A}-{R}-x-{L}-G-A. |
| Dihydropteroate synthase signature 1 | [LIVM]-x-[AG]-[LIVMF](2)-N-x-T-x-[DN]-S-[FLMI]-x-D-x-[SG]. |
| Dihydropteroate synthase signature 2 | [GE]-[SAV]-x-[LIVM](2)-D-[LIVMF]-G-[GPA]-x(2)-[STA]-x-P. |
| Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1 | C-D-K-x(2)-P-[GA]-x(3)-[GA]. |
| Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2 | [SGALC]-[LIMF]-[LIVMF]-T-D-[GA]-R-[LIVMFY]-S-[GA]-[GAV]-[ST]. |
| Disintegrins signature | C-x(2)-[GS]-x-C-C-x(1,2)-[NQRSEKD]-C-x-[FMYLVI]-x(6)-C-[RKNQ]. |
| DM DNA-binding domain signature | C-x(2)-C-x(2)-H-x(8)-H-x(3,4)-C-x(4)-C-x-C-x(2,3)-C. |
| DNA mismatch repair proteins mutL / hexB / PMS1 signature | G-F-R-G-E-[AG]-L. |
| DNA mismatch repair proteins mutS family signature | [STA]-[LIVMF]-x-[LIVM]-x-D-E-[LIVMFY]-[GCA]-[RKHAS]-[GS]-[GST]-x(4)-G. |
| DNA photolyases class 1 signature 1 | T-G-x-P-[LIVM](2)-D-A-x-M-[RA]-x-[LIVM]. |
| DNA photolyases class 1 signature 2 | [DN]-R-x-R-[LIVM]-[LIVMN]-x-[STA]-[STAQ]-F-[LIVMFA]-x-K-x-L-x(2,3)-W-[KRQ]. |
| DNA photolyases class 2 signature 1 | F-x-E-E-x-[LIVM](2)-R-R-E-L-x(2)-N-F. |
| DNA photolyases class 2 signature 2 | G-x-H-D-x(2)-W-x-E-R-x-[LIVM]-F-G-K-[LIVM]-R-[FY]-M-N. |
| DNA polymerase family A signature | R-x(2)-[GSAV]-K-x(3)-[LIVMFY]-[AGQ]-x(2)-Y-x(2)-[GS]-x(3)-[LIVMA]. |
| DNA polymerase family B signature | [YA]-[GLIVMSTAC]-D-T-D-[SG]-[LIVMFTC]-{LA}-[LIVMSTAC]. |
| DNA polymerase family X signature | G-[SG]-[LFY]-x-R-[GE]-x(3)-[SGCL]-x-D-[LIVM]-D-[LIVMFY](3)-x(2)-[SAP]. |
| DNA repair protein radC family signature | H-N-H-P-[SQ]-G. |
| DNA topoisomerase II signature | [LIVMA]-{R}-E-G-[DN]-S-A-{F}-[STAG]. |
| DNA/RNA non-specific endonucleases active site | D-R-G-H-[QLIM]-x(3)-[AG]. |
| DnaA protein signature | [IL]-[GA]-x(2)-[LIVMF]-[SGADENK]-x(0,1)-[KR]-x-H-[STPA]-[STAV]-[LIVM]-x(2)-[SGAMN]-x(3)-[LIVM]. |
| Dps protein family signature 1 | H-[FW]-x-[LIVM]-x-G-x(5)-[LV]-H-x(3)-[DE]. |
| Dps protein family signature 2 | [LIVMFY]-[DH]-x-[LIVM]-[GA]-E-R-x(3)-[LIF]-[GDN]-x(2)-[PA]. |
| Dynamin family signature | L-P-[RKT]-[GD]-[STNKEA]-[GND]-[LIVMG]-[VICA]-T-R. |
| Dynein light chain type 1 signature | H-x-[IV]-x-G-[KR]-x-F-[GA]-S-x-V-[ST]-[HY]-E. |
| E1-E2 ATPases phosphorylation site | D-K-T-G-T-[LIVM]-[TI]. |
| EF-hand calcium-binding domain | D-{W}-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-[DE]-[LIVMFYW]. |
| EGF-like domain signature 1 | C-x-C-x(2)-{V}-x(2)-G-{C}-x-C. |
| EGF-like domain signature 2 | C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C. |
| Electron transfer flavoprotein alpha-subunit signature | [LI]-Y-[LIVM]-[AT]-x-[GA]-[IV]-[SD]-G-x-[IV]-Q-[HP]-x(2)-G-x(6)-[IV]-x-A-[IV]-N. |
| Electron transfer flavoprotein beta-subunit signature | [IVAG]-x-[KR]-x(2)-[DE]-[GDE](2)-x(1,2)-[EQHF]-x-[LIV]-x(4)-P-x-[LIVM](2)-[TACS]. |
| ELO family signature | [LIV]-x-F-[LIV]-H-[VYWT]-[FY]-H-H. |
| Elongation factor 1 beta/beta'/delta chain signature 1 | [DEG](2)-[DEK]-[DE]-[LIVMF]-D-L-F-G. |
| Elongation factor 1 beta/beta'/delta chain signature 2 | [IV]-Q-S-x-D-[LIVM]-x-A-[FWM]-[DNQS]-K-[LIVM]. |
| Elongation factor P signature | K-x-[AV]-x(4)-G-x(2)-[LIVT]-x-V-P-x(2)-[LIVC]-x(2)-[GD]. |
| Elongation factor Ts signature 1 | L-R-x(2)-[TS]-[GSDNQ]-x-[GSA]-[LIVMF]-x(0,1)-[DENKAC]-x-K-[KRNEQS]-[AV]-L. |
| Elongation factor Ts signature 2 | [ELAS]-[LIVMF]-[NVCKGST]-[SCVA]-[QE]-T-D-[FS]-[VLA]-[SAT]-[KRNLAQS]. |
| Endogenous opioids neuropeptides precursors signature | C-x(3)-C-x(2)-C-x(2)-[KRH]-x(6,7)-[LIF]-[DNS]-x(3)-C-x-[LIVM]-[EQ]-C-[EQ]-x(8)-W-x(2)-C. |
| Endonuclease III family signature | [GSTENA]-x-[LIVMF]-P-x(5)-[LIVMW]-x(2,3)-[LI]-[PAS]-G-[IV]-[GA]-x(3)-[GAC]-x(2,3)-[LIVMA]-x(1,2)-[GSALVI]-[LIVMFYW]-[GANKD]. |
| Endonuclease III iron-sulfur binding region signature | C-x(3)-[KRSN]-P-[KRAGL]-C-x(2)-C-x(5)-C. |
| Endopeptidase Clp histidine active site | R-x(3)-[EAP]-x(3)-[LIVMFYT]-[LM]-[LIVM]-H-Q-P. |
| Endopeptidase Clp serine active site | T-x(2)-[LIVMF]-G-x-A-[SAC]-S-[MSA]-[PAG]-[STA]. |
| Endoplasmic reticulum targeting sequence | [KRHQSA]-[DENQ]-E-L>. |
| Endothelin family signature | C-x-C-x(4)-D-x(2)-C-x(2)-[FY]-C. |
| Enhancer of rudimentary signature | Y-D-I-[SA]-x-L-[FY]-x-F-[IV]-D-x(3)-D-[LIV]-S. |
| Enolase signature | [LIVTMS]-[LIVP]-[LIV]-[KQ]-x-[ND]-Q-[INV]-[GA]-[ST]-[LIVM]-[STL]-[DERKAQG]-[STA]. |
| Enoyl-CoA hydratase/isomerase signature | [LIVM]-[STAG]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-[LIVMST]-x-[CSTA]-[DQHP]-[LIVMFYA]. |
| Enterobacterial virulence outer membrane protein signature 1 | G-[LIVMFY]-N-[LIVM]-K-Y-R-Y-E. |
| Enterobacterial virulence outer membrane protein signature 2 | [FYW]-x(2)-G-x-G-Y-[KR]-F>. |
| Ependymins signature 1 | [DE]-[SQLM]-[KAH]-[NT]-[QEK]-[SQ]-C-[SRKH]-x-[EQKM]-[STM]-L. |
| Ependymins signature 2 | F-x-[PL]-P-[STA]-[FYT]-C-[DEQ]-[GAMI]-[LVMA]-x-[TLF]-[DE]-[DEK]. |
| Ephrins signature | [KRQ]-[LF]-[CST]-x-K-[IF]-Q-x-[FY]-[ST]-[PA]-x(3)-G-x-E-F-x(5)-[FY](2)-x(2)-[SA]. |
| EPSP synthase signature 1 | [LIVF]-{LV}-x-[GANQK]-[NLG]-[SA]-[GA]-[TAI]-[STAGV]-{N}-R-x-[LIVMFYAT]-x-[GSTAP]. |
