Protein domains in Prosite database.
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| 'Cold-shock' domain signature | [FYKH]-G-[FL]-[IL]-x(6,7)-[DER]-[LIVM]-[FQ]-x-H-x-[STKR]-x-[LIVMFYC]. |
| 'Homeobox' antennapedia-type protein signature | [LIVMFE]-[FY]-P-W-M-[KRQTA]. |
| 'Homeobox' domain signature | [LIVMFYG]-[ASLVR]-x(2)-[LIVMSTACN]-x-[LIVM]-{Y}-x(2)-{L}-[LIV]-[RKNQESTAIY]-[LIVFSTNKH]-W-[FYVC]-x-[NDQTAH]-x(5)-[RKNAIMW]. |
| 'Homeobox' engrailed-type protein signature | L-M-A-[EQ]-G-L-Y-N. |
| 11-S plant seed storage proteins signature | N-G-x-[DE](2)-x-[LIVMF]-C-[ST]-x(11,12)-[PAG]-D. |
| 14-3-3 proteins signature 1 | [RA]-N-L-[LIV]-S-[VG]-[GA]-Y-[KN]-N-[IVA]. |
| 14-3-3 proteins signature 2 | Y-K-[DE]-[SG]-T-L-I-[IML]-Q-L-[LF]-[RHC]-D-N-[LF]-T-[LS]-W-[TANS]-[SAD]. |
| 2'-5'-oligoadenylate synthetases signature 1 | G-S-x-[AG]-[KRN]-x-T-x-L-[KRN]-x(3)-[DE]-x-[DET]-[LM]-[VI]-x-F. |
| 2'-5'-oligoadenylate synthetases signature 2 | R-P-[VI]-I-L-D-P-x-[DE]-P-T. |
| 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site | [GDN]-x(2)-[LIVF]-x(3)-{VH}-{M}-[LIVMFCA]-x(2)-[LIVMFA]-{LDFY}-{KPE}-x-K-[GSTAIVW]-[STAIVQDN]-x(2)-[LIVMFS]-x(5)-[GCN]-x-[LIVMFY]. |
| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature | S-[DN]-[GA]-D-[LIVAP]-[LIVAG]-x-H-[STAC]-x(2)-[DNT]-[SAG]-x(2)-[SGA]. |
| 2Fe-2S ferredoxins, iron-sulfur binding region signature | C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C. |
| 3'5'-cyclic nucleotide phosphodiesterases signature | H-D-[LIVMFY]-x-H-x-[AG]-x(2)-[NQ]-x-[LIVMFY]. |
| 3-hydroxyacyl-CoA dehydrogenase signature | [DNES]-x(2)-[GA]-F-[LIVMFYA]-x-[NT]-R-x(3)-[PA]-[LIVMFY]-[LIVMFYST]-x(5,6)-[LIVMFYCT]-[LIVMFYEAH]-x(2)-[GVE]. |
| 3-hydroxyisobutyrate dehydrogenase signature | [LIVMFY](2)-G-L-G-x-[MQ]-G-x(2)-[MA]-[SAV]-x-[SNHR]. |
| 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature | [IVT]-[LIVMC]-[IVT]-[HS]-D-[SGAV]-[AV]-R. |
| 4-hydroxybenzoyl-CoA thioesterase family active site | [QR]-[IV]-x(4)-[TC]-D-x(2)-G-[IV]-V-x-[HF]-x(2)-[FY]. |
| 43 Kd postsynaptic protein signature | G-Q-D-Q-T-K-Q-Q-I. |
| 4Fe-4S ferredoxins, iron-sulfur binding region signature | C-x-{P}-C-{C}-x-C-{CP}-x-{C}-C-[PEG]. |
| 5'-nucleotidase signature 1 | [LIVM]-x-[LIVM](2)-[HEA]-[TI]-x-D-x-H-[GSA]-x-[LIVMF]. |
| 5'-nucleotidase signature 2 | [FYPH]-x(4)-[LIVM]-G-N-H-E-F-[DN]. |
| 6-phosphogluconate dehydrogenase signature | [LIVM]-x-[DG]-x(2)-[GAEHS]-[NQSD]-[KS]-G-[TE]-G-x-W. |
| 6-pyruvoyl tetrahydropterin synthase signature 1 | C-N-N-x(2)-G-H-G-H-N-Y. |
| 6-pyruvoyl tetrahydropterin synthase signature 2 | D-H-K-N-L-D-x-D. |
| 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature | [KRHD]-x-[GA]-[PSAE]-R-x(2)-D-[LIV]-D-[LIVM](2). |
| AAA-protein family signature | [LIVMTR]-x-[LIVMT]-[LIVMF]-x-[GATMC]-[ST]-[NS]-x(4)-[LIVM]-D-x-[AS]-[LIFAV]-x(1,2)-R. |
| ABC transporters family signature | [LIVMFYC]-[SA]-[SAPGLVFYKQH]-G-[DENQMW]-[KRQASPCLIMFW]-[KRNQSTAVM]-[KRACLVM]-[LIVMFYPAN]-{PHY}-[LIVMFW]-[SAGCLIVP]-{FYWHP}-{KRHP}-[LIVMFYWSTA]. |
| Acetate and butyrate kinases family signature 1 | [LIVMFANT]-[LIVM]-x-[LIVMA]-N-x-G-S-[ST](2)-x-[KE]. |
| Acetate and butyrate kinases family signature 2 | [LIVMFATQ]-[LIVMA]-x(2)-H-x-G-x-[GT]-x-[ST]-[LIVMA]-x-[TAVC]-x(3)-G. |
| Aconitase family signature 1 | [LIVM]-x(2)-[GSACIVM]-x-[LIV]-[GTIV]-[STP]-C-x(0,1)-T-N-[GSTANI]-x(4)-[LIVMA]. |
| Aconitase family signature 2 | G-x(2)-[LIVWPQT]-x(3)-[GACST]-C-[GSTAM]-[LIMPTA]-C-[LIMV]-[GA]. |
| Actinin-type actin-binding domain signature 1 | [EQ]-{LNYH}-x-[ATV]-[FY]-{LDAM}-{T}-W-{PG}-N. |
| Actinin-type actin-binding domain signature 2 | [LIVM]-x-[SGNL]-[LIVMN]-[DAGHENRS]-[SAGPNVT]-x-[DNEAG]-[LIVM]-x-[DEAGQ]-x(4)-[LIVM]-x-[LM]-[SAG]-[LIVM]-[LIVMT]-[WS]-x(0,1)-[LIVM](2). |
| Actins and actin-related proteins signature | [LM]-[LIVMA]-T-E-[GAPQ]-x-[LIVMFYWHQPK]-[NS]-[PSTAQ]-x(2)-N-[KR]. |
| Actins signature 1 | [FY]-[LIV]-[GV]-[DE]-E-[ARV]-[QLAH]-x(1,2)-[RKQ](2)-[GD]. |
| Actins signature 2 | W-[IVC]-[STAK]-[RK]-x-[DE]-Y-[DNE]-[DE]. |
| Acyl-CoA dehydrogenases signature 1 | [GAC]-[LIVM]-[ST]-E-x(2)-[GSAN]-G-[ST]-D-x(2)-[GSA]. |
| Acyl-CoA dehydrogenases signature 2 | [QDE]-x-{P}-G-[GS]-x-G-[LIVMFY]-x(2)-[DEN]-x(4)-[KR]-x(3)-[DEN]. |
| Acyl-CoA-binding (ACB) domain signature | [PTLV]-[GSTA]-x-[DENQA]-x-[LMFK]-x(2)-[LIVMFY]-[YV]-[GSA]-x-[FYH]-K-Q-[GSAV]-[STL]-x-G. |
| Acylphosphatase signature 1 | [LIV]-x-G-x-V-Q-[GH]-V-x-[FM]-R. |
| Acylphosphatase signature 2 | G-[FYW]-[AVC]-[KRQAM]-N-x(3)-G-x-V-x(5)-G. |
| Acyltransferases ChoActase / COT / CPT family signature 1 | [LI]-[PK]-x-[LVPQ]-P-[IVTAL]-P-x-[LIVMA]-x-[DENQAS]-[ST]-[LIVMA]-x(2)-[LY]. |
| Acyltransferases ChoActase / COT / CPT family signature 2 | R-[FYW]-x-[DA]-[KA]-x(0,1)-[LIVMFY]-x-[LIVMFY](2)-x(3)-[DNS]-[GSA]-x(6)-[DE]-[HS]-x(3)-[DE]-[GAC]. |
| Adenosine and AMP deaminase signature | [SA]-[LIVM]-[NGS]-[STA]-D-D-P. |
| Adenylate cyclase class-I signature 1 | E-Y-F-G-[SA](2)-L-W-x-L-Y-K. |
| Adenylate cyclase class-I signature 2 | Y-R-N-x-W-[NS]-E-[LIVM]-R-T-L-H-F-x-G. |
| Adenylate kinase signature | [LIVMFYWCA]-[LIVMFYW](2)-D-G-[FYI]-P-R-x(3)-[NQ]. |
| Adenylosuccinate synthetase active site | G-I-[GR]-P-x-Y-x(2)-K-x(2)-R. |
| Adenylosuccinate synthetase GTP-binding site | [QGF]-[WLCF]-G-D-E-[GA]-K-[GA]. |
| Adipokinetic hormone family signature | Q-[LV]-[NT]-[FY]-[ST]-x(2)-W. |
| ADP-glucose pyrophosphorylase signature 1 | [AG]-G-G-x-G-[STKA]-x-L-x(2)-L-[TA]-x(3)-[AST]-x-P-[AS]-[LV]. |
| ADP-glucose pyrophosphorylase signature 2 | W-[FY]-x-G-[ST]-[AS]-[DNSH]-[AS]-[LIVMFYW]. |
| ADP-glucose pyrophosphorylase signature 3 | [APV]-[GS]-M-G-[LIVMN]-Y-[IVC]-[LIVMFY]-x(2)-[DENPHKRQS]. |
| ADP-ribosylation factors family signature | [HRQT]-x-[FYWI]-x-[LIVM]-x(4)-A-x(2)-G-x(2)-[LIVM]-x(2)-[GSA]-[LIVMF]-x-[WK]-[LIVM]. |
| Adrenodoxin family, iron-sulfur binding region signature | C-x(2)-[STAQ]-x-[STAMV]-C-[STA]-T-C-[HR]. |
| Aerolysin type toxins signature | [KT]-x(2)-N-W-x(2)-T-[DN]-T. |
| Agouti domain signature | C-x(6)-C-x(6)-C-C-x(2)-C-x(2)-C-x-C-x(6)-C-x-C-x(6,9)-C. |
| Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 | [GA]-[LIVM]-[PKV]-x(0,1)-E-x(3)-[NG]-E-x(1,3)-R-[VT]-[AG]-x-[ST]-P-x-[GSTVN]-[VA]-x(2)-[LI]-x-[KRHNGSED]-x-G. |
| Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2 | [LIVM]-[LIVMF]-G-[GAV]-G-x-[AV]-[GA]-x(2)-[SA]-x(3)-[GA]-x-[SGR]-[LIVM]-[GN]-A-x-V-x(3)-[DE]. |
| Alanine racemase pyridoxal-phosphate attachment site | [SACVLG]-[AIPTV]-x(0,1)-K-[ADGS]-[DEN]-[GA]-Y-G-[HACILN]-[GD]. |
| Aldehyde dehydrogenases cysteine active site | [FYLVA]-x-{GVEP}-{DILV}-G-[QE]-{LPYG}-C-[LIVMGSTANC]-[AGCN]-{HE}-[GSTADNEKR]. |
| Aldehyde dehydrogenases glutamic acid active site | [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]. |
| Aldo/keto reductase family putative active site signature | [LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x-{LVRI}-[LIVMFA]. |
| Aldo/keto reductase family signature 1 | G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGCL]-[AS]-x(5)-[EQ]-x(2)-[LIVMCA]-[GS]. |
| Aldo/keto reductase family signature 2 | [LIVMFY]-x(8)-{L}-[KREQ]-{K}-[LIVM]-G-[LIVM]-[SC]-N-[FY]. |
| Aldose 1-epimerase putative active site | [NS]-x-T-N-H-x-Y-[FW]-N-[LI]. |
| Alkaline phosphatase active site | [IV]-x-D-S-[GAS]-[GASC]-[GAST]-[GA]-T. |
| Alkylbase DNA glycosidases alkA family signature | G-[IV]-[GK]-x-W-[ST]-[AVI]-x-[LIVMFY](2)-x-[LIVM]-x(8)-[MF]-x(2)-[ED]-D. |
| Alpha-2-macroglobulin family thiolester region signature | [PG]-x-[GS]-C-[GA]-E-[EQ]-x-[LIVM]. |
| Alpha-carbonic anhydrases signature | S-E-[HN]-x-[LIVM]-x(4)-[FYH]-x(2)-E-[LIVMGA]-H-[LIVMFA](2). |
| Alpha-conotoxin family signature | C-C-[SHYN]-x(0,1)-[PRG]-[RPATV]-C-[ARMFTNHG]-x(0,4)-[QWHDGENLFYVP]-[RIVYLGSDW]-C. |
| Alpha-galactosidase signature | G-[LIVMFY]-x(2)-[LIVMFY]-x-[LIVM]-D-[DF]-x(1,2)-W-x(3,7)-[RV]-[DNSF]. |
| Alpha-isopropylmalate and homocitrate synthases signature 1 | L-R-[DE]-G-x-Q-x(4)-{L}-x(5)-K. |
| Alpha-isopropylmalate and homocitrate synthases signature 2 | [LIVMFW]-x(2)-H-x-H-[DN]-D-x-G-x-[GAS]-x-[GASLI]. |
| Alpha-L-fucosidase putative active site | P-x(2)-L-x(3)-K-W-E-x-C. |
| Alpha-lactalbumin / lysozyme C signature | C-x(3)-C-x(2)-[LMF]-x(3)-[DEN]-[LI]-x(5)-C. |
| Amidases signature | G-[GAV]-S-[GS](2)-G-x-[GSAE]-[GSAVYCT]-x-[LIVMT]-[GSA]-x(6)-[GSAT]-x-[GA]-x-[DE]-x-[GA]-x-S-[LIVM]-R-x-P-[GSACTL]. |
| Amidation site | x-G-[RK]-[RK]. |
| Amiloride-sensitive sodium channels signature | Y-x(2)-[EQTFPMSI]-x-C-x(3)-C-x-[QTAVKS]-x(2)-[LIVMT]-[LIVMSAQ]-x(2)-C-x-C. |
| Amino acid permeases signature | [STAGC]-G-[PAG]-x(2,3)-[LIVMFYWA](2)-x-[LIVMFYW]-x-[LIVMFWSTAGC](2)-[STAGC]-x(3)-[LIVMFYWT]-x-[LIVMST]-x(3)-[LIVMCTA]-[GA]-E-x(5)-[PSAL]. |
| Aminoacyl-transfer RNA synthetases class-I signature | P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-G-[HNTG]-[LIVMFYSTAGPC]. |
| Aminopeptidase P and proline dipeptidase signature | [HA]-[GSYR]-[LIVMT]-[SG]-H-x-[LIV]-G-[LIVMNKS]-x-[IVEL]-[HNC]-[DEV]. |
| Aminotransferases class-I pyridoxal-phosphate attachment site | [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-[GNAR]-{V}-R-[LIVMA]-[GA]. |
| Aminotransferases class-II pyridoxal-phosphate attachment site | T-[LIVMFYW]-[STAG]-K-[SAG]-[LIVMFYWR]-[SAG]-{ENKR}-{TNDR}-[SAG]. |
| Aminotransferases class-III pyridoxal-phosphate attachment site | [LIVMFYWCS]-[LIVMFYWCAH]-x-D-[ED]-[IVA]-x(2,3)-[GAT]-[LIVMFAGCYN]-x(0,1)-[RSACLIH]-x-[GSADEHRM]-x(10,16)-[DH]-[LIVMFCAG]-[LIVMFYSTAR]-x(2)-[GSA]-K-x(2,3)-[GSTADNV]-[GSAC]. |
| Aminotransferases class-IV signature | E-x-[STAGCI]-x(2)-N-[LIVMFAC]-[FY]-x(6,12)-[LIVMFA]-x-T-x(6,8)-[LIVM]-x-[GS]-[LIVM]-x-[KR]. |
| Aminotransferases class-V pyridoxal-phosphate attachment site | [LIVFYCHT]-[DGH]-[LIVMFYAC]-[LIVMFYA]-x(2)-[GSTAC]-[GSTA]-[HQR]-K-x(4,6)-G-x-[GSAT]-x-[LIVMFYSAC]. |
| Ammonium transporters signature | D-[FYWS]-[AS]-G-[GSC]-x(2)-[IV]-x(3)-[SAG](2)-x(2)-[SAG]-[LIVMF]-x(3)-[LIVMFYWA](2)-x-[GK]-x-R. |
| Amyloidogenic glycoprotein extracellular domain signature | G-[VT]-[EK]-[FY]-V-C-C-P. |
| Amyloidogenic glycoprotein intracellular domain signature | G-Y-E-N-P-T-Y-[KR]. |
| Anaphylatoxin domain signature | [CSH]-C-x(2)-[GAP]-x(7,8)-[GASTDEQR]-C-[GASTDEQL]-x(3,9)-[GASTDEQN]-x(2)-[CE]-x(6,7)-C-C. |
| Anion exchangers family signature 1 | F-G-G-[LIVM](2)-[KR]-D-[LIVM]-[RK]-R-R-Y. |
| Anion exchangers family signature 2 | [FI]-L-I-S-L-I-F-I-Y-E-T-F-x-K-L. |
| Annexins repeated domain signature | [TG]-[STV]-x(8)-[LIVMF]-x(2)-R-x(3)-[DEQNH]-x(2)-{S}-x(4)-[IFY]-x(7)-[LIVMF]-x(3)-[LIVMF]-x(5)-{I}-x(5)-[LIVMFA]-x(2)-[LIVMF]. |
| Antenna complexes alpha subunits signature | [LIVFAG]-x-[GASV]-[LIVFA]-x-[IV]-H-x(3)-[LIVM]-[GSTAE]-[STANH]-x(1,3)-[STN]-W-[LIVMFYW]. |
| Antenna complexes beta subunits signature | [EQ]-x(4)-[HGQ]-x(5)-[GSTA]-x(3)-[FYV]-x(3)-[AG]-x(2)-[AV]-H-x(7)-P. |
| AP endonucleases family 1 signature 1 | [APF]-D-[LIVMF](2)-{T}-[LIVM]-Q-E-{G}-K. |
| AP endonucleases family 1 signature 2 | D-[ST]-[FY]-[RP]-[KHQ]-x(7,8)-[FYWD]-[ST]-[FYW](2). |
| AP endonucleases family 1 signature 3 | N-x-G-x-R-[LIVM]-D-[LIVMFYH]-x-[LV]-x-S. |
| AP endonucleases family 2 signature 1 | H-[GSAD]-x-Y-[LIF]-[LIMN]-N-[LIVMFCAP]-[AGC]. |
